Human immunodeficiency virus (HIV) is an infection that came into existence decades back; it spread across the African countries in the late 1970s, and is currently endemic across the world. HIV is a major public health problem all over the world, as it has claimed more than 35million lives. There were around 36.9 million individuals living with HIV at the end of 2017, and Sub-Saharan Africa remains the most affected by HIV infection with 1 in 25 adults (4.1%) living with the virus, accounting for 70% of the people living with HIV worldwide. Unfortunately, Sub-Saharan Africa continues to be the continent with the highest cases of infections and deaths from HIV/AIDS even after the implementation of various HIV/AIDS prevention methods. Fortunately, pre-exposure prophylaxis (PrEP) offers the world a novel way of curtailing the HIV/AIDS epidemic, as PrEP is highly effective for preventing HIV if it is used as prescribed. This paper discusses the urgent need for the use of PrEP in the prevention of HIV/AIDS in Sub-Saharan Africa. It is a review paper in which the meaning of PrEP was discussed, people who need PrEP were identified, the rationale for the use of PrEP for the prevention of HIV/AIDS in Sub-Saharan Africa were highlighted, and probable obstacles to the successful implementation of PrEP for the prevention of HIV/AIDS in Sub-Saharan Africa were also identified. It was concluded that to achieve the 90-90-90 goals set by UNAIDS to help end the AIDS epidemic in the world, PrEP offers a new and novel way for HIV prevention, and its implementation across all African countries is urgently needed for the prevention of HIV/AIDS in Sub-Saharan Africa.; Virus humane imunodeficijencije (HIV) je infekcija koja je nastala prije nekoliko desetljeća; proširila se afričkim zemljama kasnih sedamdesetih godina I trenutno je endemska bolest širom svijeta. HIV predstavlja veliki javnozdravstveni problem u cijeloms vijetu jer je odnio više od 35 milijuna života. Krajem 2017. Godine bilo je oko 36,9 milijuna osoba koje žive s HIV-om, a subsaharska Afrika je i dalje najviše pogođena HIV infekcijom s 1 na 25 odraslih osoba(4,1%) kojižive s virusom, što čini 70% ljudi koji žive s HIV-om širom svijeta. Nažalost, subsaharska Afrika je I dalje kontinent s najvišim brojem infekcija I smrti od HIV/AIDS-a, čak I nakon provedbe različitih metoda prevencije. Srećom, preekspozicijska profilaksa (PrEP) svijetu nudi novi način ograničavanja epidemije HIV/AIDS-a, budući da je PrEP visoko učinkovit u sprječavanju HIV-a ako se koristikako je propisano. U ovom se radu raspravlja o hitnoj potrebi korištenja PrEP-a u prevenciji HIV/AIDS-a u subsaharskoj Africi. To je pregledni rad u kojem se raspravlja o značenju PrEP-a, identificirani su ljudi kojima je potreban PrEP, istaknuta je svrha primjene PrEP-a za prevenciju HIV/AIDS-a u subsaharskoj Africi te su također identificirane moguće prepreke za uspješnu provedbu PrEP-a za prevenciju HIV/AIDS-a u subsaharskoj Africi. Zaključeno je da je za postizanje ciljeva 90-90-90 koje je UNAIDS postavio kako bi se okončala epidemija AIDS-a u svijetu, PrEP nudi novi način prevencije HIV-a, a njezina primjena u svim afričkim zemljama hitno je potrebna za prevenciju. HIV/AIDS-a u subsaharskoj Africi.