Upalne bolesti crijeva kronični su upalni poremećaji gastrointestinalnog sustava nepoznatog uzroka u koje ubrajamo Crohnovu bolest, ulcerozni kolitis i nedeterminirani kolitis. Ciljevi liječenja upalnih bolesti crijeva su postizanje i održavanje remisije bolesti, kao i mukozno cijeljenje. Biološka terapija predstavlja značajan napredak u liječenju s obzirom na to da može inhibirati upalnu kaskadu u podlozi kronične upalne bolesti te na taj način modificirati tijek i zaustaviti progresiju bolesti. S obzirom na to da je riječ o kompleksnim terapijama s potencijalno ozbiljnim nuspojavama, njihova primjena zahtijeva iskustvo i provodi se prvenstveno u specijaliziranim centrima, ali sve više u općim i županijskim bolnicama.; Inflammatory bowel disease is a chronic infammatory disorder of gastrointestinal system with unknown cause, which include Crohn’s disease, ulcerative colitis and undetermined colitis. The aim of treatment is to induce clinical remission of disease and to achieve mucousal healing. Biological therapy is a big progress in treatment because it can inhibite inflammatory cascade found in the base of chronic inflammatory disease, modify disease and stop its progression. That therapy is very complex with many possibly serious side effects, so its use requires experience and it is used mostly in specialised centers, but also more and more in other hospitals.