Aminoglikozidni antibiotici se upotrebljavaju u terapiji bolesti, kao aditivi stočnoj hrani, ili kao promotori rasta kako bi se poticao rast životinja. Dio apliciranih antibiotika se akumulira unutar različitih tkiva, a dio se izlučuje kroz urin, izmet, mlijeko i jaja tretiranih životinja, bilo kao nemetabolizirani ishodišni spojevi, ili kao njihovi metaboliti. To može predstavljati stvarnu prijetnju potrošaču, kroz izloženost ostacima antibiotika, a moguć je razvoj i prijenos antibiotičke rezistencije ili pojava alergija i drugih zdravstvenih poremećaja. Negativni aspekti uporabe antibiotika kod životinja potvrđuju važnost kontinuiranog praćenja ostataka antibiotika, kao i razvoja učinkovitih analitičkih tehnika za utvrđivanje njihove bioakumulacije u tkivima i precizne koncentracije ostataka antibiotika u proizvodima životinjskog podrijetla namijenjenih ljudskoj prehrani.; Aminoglycoside antibiotics are used for disease control, as feed additives, or as growth promoters in order to improve feed utilization and animal production. Applied antibiotics are partly accumulated in various tissues and partly excreted via urine, feces, milk and eggs of treated animals as non-metabolized parent compounds or as their metabolites. This may pose a real threat to the consumer, either through exposure to the antibiotic residues, or through the development and transfer of antibiotic resistance and occurrence of allergies and other health disturbances. The negative aspects of the use of antibiotics in animal diets confirm the importance of continuous monitoring of antibiotic residues in both live animals and animal products, and importance of the development of effective analytical techniques to determine their bioaccumulation in animal tissues and the precise concentrations of antibiotic residues in food products of animal origin.