Duhanski dim prvi je sprječiv uzrok smrti, a pušenje je danas sve manje prihvatljivo u mnogim društvenim segmentima. Radi vlastitog opstanka na tržištu duhanska industrija posljednjih desetak godina razvija alternativne proizvode – ENDS (engl. electrical nicotine delivery system) i HNBT (engl. heat-not-burn), kako bi ponudila manje štetnu opciju potrošačima. Proizvođači e-cigareta pozivaju se na deklaraciju GRAS, koja se odnosi isključivo na konzumiranje ingestijom, dok je već i udisanje samog aerosola, koji nastaje kod oba navedena proizvoda, štetno. E-cigarete stvaraju aerosol zagrijavanjem e-tekućine, dok se HNBT uređaji temelje na zagrijavanju komprimiranog lišća duhana, čime nastaju štetni spojevi iako u znatno manjim koncentracijama nego kod konvencionalnih cigareta.; Tobacco smoke is the leading preventable cause of death worldwide, and smoking has become a less desirable habit in many social segments. Therefore, during the last decade, the tobacco industry has developed some alternatives – ENDS and HNBT products, in order to offer a less harmful option for consumers. E-cigarette manufacturers are referred to the GRAS declaration which refers exclusively to ingestion, while the inhalation of the aerosol itself, which occurs in both of these products, is harmful. E-cigarettes create an aerosol by heating e-liquid, and HNBT devices are based on heating the coated tobacco leaves thus producing harmful compounds although at considerably lower concentrations than conventional cigarettes.