This paper presents the methodology for the development of an optimization model for the optimization of the cross-section dimensions of a bridge crane girder designed as a welded I-profile. To carry out this optimization, the CAD/CAE software package CATIA V5 was used. In order to develop an optimization model, a CAD geometrical model and structural analysis model were developed. Optimization was carried out by the iterative method using a simulated hardening algorithm. Additionally, the optimization process is carried out by using the PEO (Product Engineering Optimization) CATIA module that contains tools for setting the optimization criteria, design parameters, constraints, and algorithms. The goal of the optimization is to achieve the minimal mass of the girder, while satisfying all functional and geometrical constraints. As a result of the optimization process, minimal girder dimensions were obtained and due to that, a minimal amount of material can be used for the manufacturing of the girder.