OpisIn this report we review our results on the development of 1,2-annulated adamantane heterocyclic derivatives and we discuss the structure-activity relationships obtained from their biological evaluation against influenza A virus. We have designed and synthesized numerous potent 1,2-annulated adamantane analogues of amantadine and rimantadine against influenza A targeting M2 protein the last 20 years. For their synthesis we utilized the key intermediates 2-(2-oxoadamantan-1-yl)acetic acid and 3-(2-oxoadamantan-1-yl)propanoic acid, which were obtained by a simple, fast and efficient synthetic protocol. The latter involved the treatment of protoadamantanone with different electrophiles and a carbon-skeleton rearrangement. These ketoesters offered a new pathway to the synthesis of 1,2-disubstituted adamantanes, which constitute starting materials for many molecules with pharmacological potential, such as the 1,2-annulated adamantane heterocyclic derivatives. To obtain additional insight for their binding to M2 protein three structurally similar 1,2-annulated adamantane piperidines, differing in nitrogen position, were studied using molecular dynamics (MD) simulations in palmitoyl-oleoyl-phosphatidyl-choline (POPC) hydrated bilayers.
OpisThe personalization of footwear in terms of dimension and shape is of the utmost importance and is nowadays considered vitally important by interdisciplinary professions (medical, footwear, ergonomics ...), since inadequately manufactured footwear inevitably results in unwanted pathological conditions of the feet.The aim of this study is to scientifically determine the application of automated 3D digitization of spatial anthropometric foot measurement in relation to the frequency of incorrectly selected footwear based on traditional methods of measurement and selection.Among the examined individuals, both male and female, it was found that more than two thirds of people wear footwear that ergonomically does not fit the basic anthropometric footwear measurements, both in width and length of their feet.There is medical evidence that wearing inappropriate footwear is closely related to pain and wounds on the feet, and that prolonged wearing leads to pathological changes of the feet, such as foot and toe deformation.In the scope of taking measures, traditional methods of determining foot morphology are not sufficient to accurately define the shape and size, in contrast to the modern approach of using 3D scanners and digital methods of measuring virtual 3D models, which enable a very accurate and quick personalization of a large amount of anthropometric data concerning foot morphology.
OpisNa području Podravine i Prigorja od 1874. godine, kada su osnovane Đurđevačka i Križevačka imovna općina, postoji organizirano šumarstvo i gospodarenje najvećim nacionalnim blagom. Dakle, šumama ovoga područja sustavno se brine punih 145 godina. U radu je predstavljen povijesni prikaz zakonskih propisa vezanih za šumarstvo promatranog područja te osnivanje i djelovanje Đurđevačke imovne općine, te šumskih uprava odnosno šumarija. Since 1874, when the property districts of Đurđevac and Križevci were established, the areas of Podravina and Prigorje were marked by organized forestry and management of the most valuable national asset. It can be stated that the forests of this area have been systematically taken care of for 145 years. The paper presents a historical outline of law regulations related to forestry of the researched area, along with foundation and activity of the property district of Đurđevac aswell as forestry districts or regional forestry offices.
OpisThe Balanced Scorecard (BSC) is a tool for strategic management that is used in many companies and organizations worldwide, both in the publicand private sector. With this purpose it has also been used in healthcare organizations and institutions but there are not many studies on the implementation of BSC methodology in the day-to-day clinical laboratory. This review shows the strategy for the development of a BSC, which includes theoretical perspective objectives, as well as some indicators and goals with which the monitoring and quantitative measurement of the achievements of a strategic plan in a clinical laboratory can be done. Moreover, the results of the indicators allow the prioritization of the initiatives to be implemented each year.The methodology for the development of the proposed BSC includes the following steps: definition of theoretical objectives of each of the perspectives most used in the management of a clinical laboratory (customers, financial, internal processes and learning) taking into account the vision and the organizational model of the laboratory; creation of a strategic map of perspective objectives; definition of the relevant indicators to follow up on the objectives in a quantitative manner and establishment of the goals. Whether or not the laboratory is a reference laboratory, in which specific and infrequent analysis and health population programs are performed, is another fact to take into account. In this review a BSC for a reference clinical laboratory of the Spanish public sector is shown.
OpisIn its initial part, the article presents an analysis of the definition of intellectual disability and follows its development over the past half century. In order to diagnose an intellectual disability, it is important not only to demonstrate an overall level of intelligence that is at least two standard deviations below the median score, but also to take into account the concurrent criterion of developmental age. Moreover, as discussed in this article, defining an intellectual disability also requires addressing limitations in adaptive behaviour, i.e. cognitive, social and practical functioning skills. These diagnostic criteria are met by the “Adaptive Behavior Assessment System” (ABAS), published originally in 2000 by Harrison and Oakland. Its third edition came out in 2015. ABAS-based evaluations find a wide variety of uses, including assessing adaptive behaviour of people with intellectual disabilities, diagnosing and classifying disabilities and disorders, documenting and monitoring progress over time, and determining entitlement to disability benefits. The instrument has many strengths, but it also exhibits limitations. For example, comprehensive examination is only possible if the localised adaptations of ABAS are suited for people in the age bracket of 0-89 years. The effective use of this instrument is also dependent on its compatibility with the formal disability assessment system and with the strategies for working with students who have intellectual disabilities. The level of this compatibility should be no less than the American variant. Only then will ABAS-3 be fully adaptable to the purpose for which the assessment is developed, and the results obtained will be useful and properly applied.
OpisThis article will discuss the issue of the baptisim of the Holy Spirit: what it is, how is it manifested, and what are its fruits. In the introduction, the problem and the questions pertaining to the Holy Spirit baptism are stated together with the thesis that will be tested. The thesis is that the baptism of the Holy Spirit biblically understood is a unique and unrepeatable event universal to all Christians, which happens instantaneously with salvation (when the believer is placed in Christ and joined to his body) and that this baptism is not marked by any immediate and special outward sign. First, this article will present different views on the doctrine of Holy Spirit baptism with historical developments of the views. Then it will deal with biblical data, focusing on all major passages. Special attention will be given to the Book of Acts, and “the second blessing” theology, which is the crux of the doctrine. Then the relation of hermeneutics and experience will also be discussed. Finally, the conclusion and the practical implications of the baptism of the Holy Spirit and biblical admonishments for the Christian life will be given. Ovaj članak bavit će se krštenjem u Duhu Svetome: što ono zapravo jest, kako se manifestira i koji su njegovi plodovi. U uvodu je prvo iznesena problematika i pitanja koja se vežu uz temu krštenja u Duhu, zajedno s tezom koja će biti testirana. Teza je da je krštenje u Duhu Svetome biblijski najrazumljivije ako se shvati kao jedinstven i neponovljiv događaj, svojstven svim kršćanima, a koji se događa u trenutku spasenja te da ga ne prate nikakvi trenutni i izvanjski znaci. U prvom su dijelu članka prezentirani različiti pogledi na doktrinu krštenja u Duhu Svetome i njihovi povijesni razvoji. Tada se prelazi na analizu biblijskih podataka, a u fokusu su svi glavni odjeljci koji se bave tom temom. Poseban je naglasak stavljen na knjigu Djela apostolskih i teologiju „drugog blagoslova”, koja se nalazi u središtu debate. Zatim se raspravlja o odnosu hermeneutike i iskustva. Konačno, u zaključku daje se praktičan pogled na krštenje u Duhu te biblijski poticaj na kršćanski život.