beta
Probrano po
Povezani zapisi:

Naslov portalaDigitalne zbirke NSK
  
rrep
 
14.746 (1-10)
Naslov1,2-annulated adamantane heterocyclic derivatives as anti-influenza Α virus agents / Vasiliki Pardali, Erofili Giannakopoulou, Athina Konstantinidi, Antonios Kolocouris, Grigoris Zoidis.
Materijalni opisIlustr.
Način izrade datotekeizvorno digitalna građa
Vrstačlanak
OpisIn this report we review our results on the development of 1,2-annulated adamantane heterocyclic derivatives and we discuss the structure-activity relationships obtained from their biological evaluation against influenza A virus. We have designed and synthesized numerous potent 1,2-annulated adamantane analogues of amantadine and rimantadine against influenza A targeting M2 protein the last 20 years. For their synthesis we utilized the key intermediates 2-(2-oxoadamantan-1-yl)acetic acid and 3-(2-oxoadamantan-1-yl)propanoic acid, which were obtained by a simple, fast and efficient synthetic protocol. The latter involved the treatment of protoadamantanone with different electrophiles and a carbon-skeleton rearrangement. These ketoesters offered a new pathway to the synthesis of 1,2-disubstituted adamantanes, which constitute starting materials for many molecules with pharmacological potential, such as the 1,2-annulated adamantane heterocyclic derivatives. To obtain additional insight for their binding to M2 protein three structurally similar 1,2-annulated adamantane piperidines, differing in nitrogen position, were studied using molecular dynamics (MD) simulations in palmitoyl-oleoyl-phosphatidyl-choline (POPC) hydrated bilayers.
rrep
1
Naslov1tes Banal Rgmt. No. 10 (1, 3) ; 2tes Banal Gränz Regiment No. 11.
rrep
2
Naslov2nd International Colloquium on Smart Grid Metrology (SMAGRIMET) : proceedings ; Split, Croatia April 9-12, 2019. / editors Branimir Ivšić, Goran Petrović, Martin Dadić.
ImpresumZagreb : University of Zagreb, Faculty of Electrical Engineering and Computing, 2019.
Materijalni opis1 online jedinica građe (38,5 MB).
Vrsta publikacijeknjigae-knjiga
rrep
3
Naslov3D scanner application in the function of digital foot antropometry : (FootSABA 3D Foot Scanner) / Sarajko Baksa, Ines Baksa, Budimir Mijović.
Materijalni opisIlustr., graf. prikazi.
Način izrade datotekeizvorno digitalna građa
Vrstačlanak
OpisThe personalization of footwear in terms of dimension and shape is of the utmost importance and is nowadays considered vitally important by interdisciplinary professions (medical, footwear, ergonomics ...), since inadequately manufactured footwear inevitably results in unwanted pathological conditions of the feet.The aim of this study is to scientifically determine the application of automated 3D digitization of spatial anthropometric foot measurement in relation to the frequency of incorrectly selected footwear based on traditional methods of measurement and selection.Among the examined individuals, both male and female, it was found that more than two thirds of people wear footwear that ergonomically does not fit the basic anthropometric footwear measurements, both in width and length of their feet.There is medical evidence that wearing inappropriate footwear is closely related to pain and wounds on the feet, and that prolonged wearing leads to pathological changes of the feet, such as foot and toe deformation.In the scope of taking measures, traditional methods of determining foot morphology are not sufficient to accurately define the shape and size, in contrast to the modern approach of using 3D scanners and digital methods of measuring virtual 3D models, which enable a very accurate and quick personalization of a large amount of anthropometric data concerning foot morphology.
rrep
5
Naslov3D-tiskani oralni dozirni oblici punjeni disperzijom ulja i djelatne tvari / Andrea Milićević, Matija Gretić, Gordana Matijašić.
Materijalni opisIlustr.
Način izrade datotekeizvorno digitalna građa
Vrstačlanak
OpisU ovom radu ispitana je mogućnost izrade oralnih dozirnih oblika tehnologijom 3D-tiska. Printani oblici podvrgnuti su in vitro ispitivanju oslobađanja djelatne tvari a rezultati su obrađeni u dodatku za Microsoft Excel, DDSolver. Proizvedeno je šest različitih čvrstih pripravaka. Rezultati ispitivanja oslobađanja djelatne tvari pokazali su profile oslobađanja s početnom vremenskom zadrškom, funkcijski povezanom s debljinom stijenke oblika. Profili su dobro opisani Peppas-Sahlinovim modelom. Pokazano je da tehnologija 3D-tiska ima potencijal postati metodom za jednostavnu i brzu izradu personaliziranih dozirnih oblika s odgođenim oslobađanjem.In this study, the possibility of producing pharmaceutical dosage forms by 3D printing technology is examined. In vitro dissolution tests were performed with printed dosage forms, and the results analysed in Microsoft Excel Add-In, DDSolver. 3D printing has provided six different models of solid dosage forms. The results of dissolution test have shown release profiles with initial time delay. The profiles are described by the Peppas-Sahlin model. It is shown that 3D printing technology has the potential to become a method for quick and simple production of personalized dosage forms with delayed release.
rrep
6
Naslov3 pjesme na tekstove Vladimira Vidrića / [Branimir Sakač].
Materijalni opis13 str. ; 35 cm.
rrep
7
Naslov3. zagrebački salon / I. [Ivan] Picelj.
Impresum[Zagreb], 1968.
Materijalni opis1 plakat : sitotisak ; 98 x 65 cm.
rrep
9
Naslov5. zagrebačka izložba jugoslavenskog crteža / Ivan Picelj.
ImpresumZagreb : Kabinet grafike jugoslavenske akademije znanosti i umjetnosti, 1975.
Materijalni opis1 plakat : sitotisak ; 84 x 60 cm.
rrep
10
14.746 (1-10)